MEDICAL AND BIOLOGICAL EFFECTS OF THE COMBINED APPLICATION OF HETEROCYCLIC COMPOUNDS WITH CHEMICAL DRUGS IN VIVO
Abstract
Resulting from the conducted study pain attenuation takes place with the development of the tumor process in AF-line mice. This regularity is being transformed, but it is preserved under chemotherapy both in isolation and in combination with heterocyclic compounds. In a follow-up the pain threshold is being restored. Therefore, weakening of pain threshold in the initial stage of tumor development is a reflection of weakening of defensive (nociceptive) reactions.
Downloads
References
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. / K. Coffey [et al.] // PLoS One [Electronic resource]. – 2012. – Vol. 7, № 10. – P. e45539.
Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discover / Teffera Y. [et al.] // Chem Res Toxicol. – 2010. – Vol.23, № 11. – P.1743-1752
Anticancer Potential of Thiazole Derivatives: A Retrospective Review. / Jain S [et al.] // Mini Rev Med Chem. – 2018 – Vol.18, № 8. –P.640-655
Zhang W, Li C, Shen C, Liu Y, Zhao X, Liu Y, Zou D, Gao Z, Yue C. Prodrug-based nano-drug delivery system for co-encapsulate paclitaxel and carboplatin for lung cancer treatment // Drug Deliv. 2016 – Vol.23, № 7. – R.2575-2580
Habriev, R.U. Rukovodstvo po eksperimentalnomu (doklinicheskomu) izucheniyu novyih farmakologicheskih veschestv // Vtoroe izd., pererab. i dop. - M.: Meditsina, 2005. - 832 s.
Abstract views: 0 PDF Downloads: 0
Copyright (c) 2018 Т. А. Гуринович
This work is licensed under a Creative Commons Attribution 4.0 International License.
